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Midfielders Dele Alli and Jesse Lingard are left Gareth Southgates squad for the Euro 2020 qualifiers away to Bulgaria and the Czech Republic.
Even while striker Tammy Abraham, his Chelsea team-mate, has been chosen a is for protector Fikayo Tomori.
Manchester City right-back Kyle Walker has been omitted.
England play the Czechs on 11 October and Bulgaria on 14 October.
Liverpool midfielder Alex Oxlade-Chamberlain misses out, although everton midfielder Fabian Delph has been remembered.
Injured Manchester United right-back Aaron Wan-Bissaka is not included.
There have been some hard choices to make, said Southgate. It is an exciting squad, with players really much in form.
There is still a focus on the evolution of younger players surrounded by good experience
Abraham, 22, had stated he hadnever decided yet on his global future as he is also eligible to play for Nigeria, with only played for England in 2 friendlies rather than a competitive game.
Although the same also applies to Tomori who played for Canada if he performs against Bulgaria or the Czechs, he wont have the capacity to switch allegiance.
Its not ethically right to give somebody a cap only so they cant play for someone else, said Southgate.
He and Fikayo Tomori are both on merit and have become part of our junior system right the way through, so we see them as English players and they have a enormous desire to play for England at senior level.
Abraham has five goals in 10 matches in all competitions for Chelsea so far this year and is joint second at the Premier Leagues top-scorers chart.
It was a fairly easy decision [to pick him] as hes the leading English goalscorer in the league, said Southgate.
Abraham was a part of this England Under-21 squad in the European Championship, and played for England in friendly draws at 2017 with Germany and Brazil this summer.
We put him into the group quite youthful, when we were changing the complexion of exactly what exactly we had been doing, added Southgate.
That was somewhat early for him because of the opportunity given to him by Frank Lampard in Chelsea, weve brought him back in.
This is currently a excellent chance for Tammy.
Goalkeepers: Tom Heaton (Aston Villa), Jordan Pickford (Everton), Nick Pope (Burnley)
Defenders: Trent Alexander-Arnold (Liverpool), Ben Chilwell (Leicester), Joe Gomez (Liverpool), Michael Keane (Everton), Harry Maguire (Manchester United), Tyrone Mings (Aston Villa), Danny Rose (Tottenham), Fikayo Tomori (Chelsea), Kieran Trippier (Atletico Madrid)
Midfielders: Ross Barkley (Chelsea), Fabian Delph (Everton), Jordan Henderson (Liverpool), James Maddison (Leicester), Mason Mount (Chelsea), Declan Rice (West Ham), Harry Winks (Tottenham)
Forwards: Tammy Abraham (Chelsea), Harry Kane (Tottenham), Marcus Rashford (Manchester United), Jadon Sancho (Borussia Dortmund), Raheem Sterling (Manchester City), Callum Wilson (Bournemouth)
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