How Ketogenic Diets and Blueberries Make Your Brain Work Better

How Ketogenic Diets and Blueberries Make Your Brain Work Better

Robert Krikorian is Professor in the Department of Psychiatry & Behavioral Neuroscience and Director of the Cognitive Aging Program at the University of Cincinnati Academic Health Center. His clinical and research interests include changes in cognition with aging, the influence of health conditions on memory decline and risk for Alzheimer’s disease, and approaches to delay progression of neurodegeneration. His current research involves investigations of the effects of dietary manipulation and non-pharmaceutical interventions, such as berry fruit supplementation and ketogenic diets, on neurocognitive function in middle-aged and older adults.

Learn about:
1:06 – Dr. Krikorian’s unique scientific career and how he arrived at his current interest
8:04 – Dr. Krikorian’s research on ketogenic diets and mild cognitive impairment (pre-dementia)
14:47 – The relationship Dr. Krikorian has found between insulin and cognitive function
17:18 – Improvements in other neurochemicals after patients adopted a low carb diet
19:55 – Autophagy and ketone metabolism
22:16 – Why reducing carbs (and protein) is more important for ketone generation than eating fat
25:15 – The effect of ketones on biomarkers and other features of Alzheimer’s disease
27:45 – The diabetic brain / “Type 3 diabetes” theory of Alzheimer’s disease
31:40 – Another housecleaning enzyme – Insulin Degrading Enzyme – and its relationship to Alzheimer’s
32:30 – How young people can optimize their brains
37:09 – Dr. Krikorian’s thoughts on MCT oil and exogenous ketones
41:30 – Why Dr. Krikorian became interested in berries and anthocyanin as a cognitive-enhancing food
50:12 – Learn Dr. Krikorian’s own diet and supplement regimen (he’s kind of a badass)


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